Ortho Tri-Cyclen should not be used if you have a history of blood clots, stroke, heart attack, breast cancer, or certain types of liver disease. You should also avoid Ortho Tri-Cyclen if you are currently pregnant or breastfeeding.
Several medications can interact with Ortho Tri-Cyclen, potentially reducing its effectiveness or causing adverse effects. These include some antibiotics (like rifampin and rifabutin), anticonvulsants (like phenytoin and carbamazepine), and certain HIV medications. Herbal supplements, such as St. John’s Wort, can also interfere.
Medications that Decrease Ortho Tri-Cyclen Effectiveness
| Antibiotics | Rifampin, Rifabutin | Reduced contraceptive effectiveness |
| Anticonvulsants | Phenytoin, Carbamazepine, Lamotrigine | Reduced contraceptive effectiveness; increased risk of breakthrough bleeding |
| HIV Medications | Ritonavir, Efavirenz, Nevirapine | Reduced contraceptive effectiveness |
| Herbal Supplements | St. John’s Wort | Reduced contraceptive effectiveness |
Other Potential Interactions
Ortho Tri-Cyclen may also interact with medications affecting liver enzymes, potentially altering its metabolism. Always inform your doctor and pharmacist of all medications, including over-the-counter drugs and supplements, you are taking before starting Ortho Tri-Cyclen. This allows for proper monitoring and management of potential interactions and ensures your safety and the effectiveness of your birth control.
