Prednisone is a synthetic corticosteroid, a more potent form of cortisone. Doctors prescribe prednisone far more often due to its superior efficacy and longer duration of action.
Cortisone, a naturally occurring hormone, offers weaker anti-inflammatory and immunosuppressive effects compared to prednisone. It’s often used for short-term relief of inflammation, particularly in conditions like allergic reactions.
Prednisone’s longer half-life means fewer doses are necessary for the same therapeutic effect. This translates to simpler treatment regimens for patients.
However, both medications carry risks, including increased blood sugar, weight gain, and potential for weakening bones with prolonged use. Always follow your doctor’s instructions regarding dosage and duration of treatment. Prednisone’s stronger effect necessitates careful monitoring for side effects.
Choosing between cortisone and prednisone depends entirely on the specific condition and its severity. Your physician will determine the most appropriate medication and dosage based on your individual needs.
For severe inflammation or autoimmune diseases, prednisone’s stronger action provides a more suitable therapeutic response. Mild inflammation, however, might respond adequately to cortisone’s gentler effect, minimizing potential side effects.
Always discuss potential risks and benefits with your doctor before starting any corticosteroid treatment. They will help you make an informed decision regarding your specific health situation.


