Yes, lisinopril and indomethacin can interact, potentially reducing the effectiveness of lisinopril. Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), can decrease the amount of potassium excreted by the kidneys. Lisinopril, an ACE inhibitor, already lowers blood pressure partly by increasing potassium levels. This combined effect may lead to hyperkalemia (high potassium levels in the blood), a potentially serious condition.
The risk is higher for individuals with pre-existing kidney problems or those already taking potassium-sparing diuretics. Careful monitoring of potassium levels is necessary if you are taking both medications. Your doctor should regularly check your potassium levels via blood tests.
Symptoms of hyperkalemia include muscle weakness, fatigue, nausea, and irregular heartbeat. If you experience these symptoms, contact your doctor immediately.
Your doctor may adjust your dosage of lisinopril or indomethacin, or suggest alternative medications. Open communication with your healthcare provider is vital to managing this potential interaction and ensuring your safety.
Always inform your doctor and pharmacist of all medications you are taking, including over-the-counter drugs and supplements, to avoid harmful drug interactions.
