Combining ciprofloxacin and oxycodone increases your risk of seizures. Ciprofloxacin can lower the seizure threshold, meaning it makes seizures more likely. Oxycodone, an opioid, can also contribute to this risk. Monitor for signs of seizures, including unusual jerking movements, loss of consciousness, or convulsions. Report any changes immediately to your doctor.
Ciprofloxacin can also affect how your body processes oxycodone. This might mean oxycodone’s effects are stronger or last longer than usual, leading to increased drowsiness, slowed breathing, or even overdose. Pay close attention to how you’re feeling. Don’t hesitate to contact your physician if you experience unusual side effects.
The combination may also increase the risk of QTc prolongation, a heart rhythm abnormality. This is particularly relevant for people with pre-existing heart conditions. Regular heart monitoring might be necessary if you’re taking both medications. Discuss this with your cardiologist if applicable.
Always inform your doctor and pharmacist about all medications you are taking, including over-the-counter drugs and supplements. They can provide personalized advice on managing potential interactions and adjusting dosages as needed. Open communication is key to safe medication management.
Never stop taking prescribed medications without consulting your doctor. Abruptly stopping oxycodone, in particular, can lead to withdrawal symptoms. Your healthcare provider will guide you through a safe and appropriate tapering schedule if necessary.


