Etodolac can interact negatively with several medications. Avoid concurrent use with NSAIDs, aspirin, or other anticoagulants like warfarin. This combination increases your bleeding risk. Similarly, using Etodolac with lithium can raise lithium levels, potentially leading to toxicity. Monitor lithium levels closely if you’re taking both.
Specific Interactions and Precautions
Etodolac interacts with ACE inhibitors, increasing the risk of kidney problems. Patients with pre-existing kidney disease should exercise caution and have regular kidney function tests. Concomitant use with methotrexate increases the risk of methotrexate toxicity; close monitoring is needed. Inform your doctor of all medications you are taking, including over-the-counter drugs and herbal supplements, to minimize potential interactions.
Contraindications include a known allergy to etodolac or other NSAIDs. Pregnant women, especially during the third trimester, and breastfeeding mothers should avoid etodolac. Patients with a history of gastrointestinal bleeding or ulcers should also avoid it. People with severe heart failure or uncontrolled hypertension should consult a doctor before starting etodolac treatment.
