Roxithromycin, like other macrolides, interacts with several medications. Avoid concurrent use with ergot alkaloids (like ergotamine or dihydroergotamine) due to the risk of ergotism, characterized by peripheral vasoconstriction and symptoms such as limb pain and paresthesia. This interaction stems from the inhibition of the metabolism of these alkaloids by roxithromycin.
Interactions with Other Medications
Simultaneous administration of roxithromycin and the anticoagulant warfarin may potentiate the anticoagulant effect, increasing bleeding risk. Close monitoring of the INR (International Normalized Ratio) is necessary. Roxithromycin also interacts with certain statins, potentially raising the risk of myopathy. Consult your doctor before combining roxithromycin with medications like simvastatin or atorvastatin. Furthermore, roxithromycin can increase the plasma concentrations of theophylline, leading to theophylline toxicity. Careful monitoring of theophylline levels and dose adjustment may be required.
Contraindications
Avoid roxithromycin if you have a known hypersensitivity to macrolide antibiotics, including erythromycin or azithromycin. A history of severe liver disease also represents a contraindication. Pregnancy and breastfeeding require careful consideration; discuss the risks and benefits with your doctor before using roxithromycin. Be aware that roxithromycin is not recommended for children under 12 years of age.
Specific Considerations
Always inform your doctor or pharmacist about all medications, including over-the-counter drugs and herbal supplements, you are taking before starting roxithromycin. This allows for the identification of potential interactions and minimizes the risk of adverse events. This includes medication taken for other conditions or health issues.
