Amoxicillin/clavulanate can interact with certain medications. Always inform your doctor about all medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. This allows them to assess potential interactions and adjust your treatment plan as needed.
Specifically, concurrent use with methotrexate can increase the risk of methotrexate toxicity. Close monitoring is advised. Similarly, anticoagulants like warfarin may see their effects altered, requiring careful dosage adjustments and monitoring of INR levels. Allopurinol, used to treat gout, may increase the risk of skin reactions when combined with amoxicillin/clavulanate.
Certain antibiotics, including amoxicillin/clavulanate, can decrease the effectiveness of oral contraceptives. Consider using alternative contraception methods during treatment.
| Methotrexate | Increased risk of toxicity | Close monitoring of blood counts and symptoms |
| Anticoagulants (e. g., warfarin) | Altered anticoagulant effect | Frequent INR monitoring and potential dose adjustment |
| Allopurinol | Increased risk of skin rash | Careful observation for skin reactions |
| Oral contraceptives | Reduced effectiveness | Use alternative contraception |
Contraindications include a known allergy to penicillin or cephalosporin antibiotics. Individuals with a history of severe allergic reactions to these antibiotics should avoid amoxicillin/clavulanate. Pregnant or breastfeeding women should consult their doctor before using this medication.
