Levetiracetam generally shows good tolerability, but certain interactions and precautions are necessary to consider. Avoid concurrent use with valproic acid; combining these medications may increase levetiracetam levels, potentially leading to adverse effects.
Monitor patients closely for increased sedation if using levetiracetam with other central nervous system depressants, such as opioids or benzodiazepines. Dosage adjustments may be necessary.
Renal impairment significantly affects levetiracetam clearance. Reduce the dose for patients with moderate or severe kidney disease to prevent accumulation and toxicity. Regularly monitor kidney function.
While rare, serious skin reactions like Stevens-Johnson syndrome have been reported. Discontinue levetiracetam immediately if such reactions occur. Patients should be advised to seek medical attention promptly for any new or worsening skin rashes.
Inform your doctor about all medications, including over-the-counter drugs and herbal supplements, before starting levetiracetam. This ensures proper management of potential drug interactions.
Pregnancy and breastfeeding require careful consideration. Discuss the risks and benefits with your doctor before using levetiracetam during pregnancy or while breastfeeding.
Always follow your doctor’s prescribed dosage and administration instructions. Do not abruptly stop taking levetiracetam; gradual dose reduction is required to minimize withdrawal symptoms.
