Always inform your doctor or pharmacist of all medications you are taking, including over-the-counter drugs, herbal remedies, and supplements. Acetaminophen/codeine can interact negatively with several drug classes.
Medications that Increase Risk of Bleeding
- Blood thinners (anticoagulants): Warfarin, heparin, and others increase bleeding risk when combined with acetaminophen/codeine. Close monitoring is necessary. NSAIDs (Nonsteroidal anti-inflammatory drugs): Ibuprofen, naproxen, and others can also raise the risk of stomach ulcers and bleeding when taken with acetaminophen/codeine.
Medications that Affect the Liver
- Other acetaminophen-containing products: Combining with other acetaminophen products can lead to acetaminophen overdose, causing serious liver damage. Carefully check labels! Certain antibiotics: Some antibiotics may affect how your liver processes acetaminophen/codeine. Your doctor can assess potential risks.
Medications Affecting the Central Nervous System
Opioids: Combining acetaminophen/codeine with other opioids (like morphine, oxycodone) significantly increases the risk of respiratory depression, sedation, and overdose. This combination is dangerous and should be avoided unless explicitly prescribed by a doctor. Benzodiazepines: Drugs like diazepam (Valium) and alprazolam (Xanax) enhance the sedative effects of codeine, potentially leading to excessive drowsiness or breathing problems. Concomitant use requires careful monitoring. Muscle relaxants: Combining with muscle relaxants intensifies sedative effects. Monitor for dizziness, weakness, and respiratory issues.
This list is not exhaustive. Always consult your doctor or pharmacist before combining acetaminophen/codeine with any other medication to prevent harmful interactions.
