Always inform your doctor about all medications you are taking, including over-the-counter drugs, herbal supplements, and recreational drugs. Cialis (tadalafil) can interact negatively with several medications, potentially leading to serious side effects. This includes nitrates, often prescribed for chest pain, as combining them with Cialis can cause a dangerous drop in blood pressure.
Specific Medication Interactions
Alpha-blockers, used to treat high blood pressure and enlarged prostate, can increase the risk of low blood pressure when taken with Cialis. Similarly, medications for HIV/AIDS, such as ritonavir and indinavir, can increase Cialis’s levels in your blood, potentially intensifying its effects and side effects. Grapefruit juice also interacts with Cialis, inhibiting its metabolism and raising its concentration in the blood. Avoid grapefruit juice while taking Cialis.
Before starting Cialis, discuss potential interactions with your physician. This proactive step ensures you understand any risks and allows for safer medication management. Never self-medicate or alter your dosage without consulting your doctor. Your health and safety are paramount.


