Always inform your doctor about all medications you are taking, including over-the-counter drugs, supplements, and herbal remedies, before starting sildenafil. This is crucial for preventing potentially harmful interactions.
Sildenafil can interact negatively with nitrates, often found in medications for chest pain (angina). This combination can cause a dangerous drop in blood pressure. Avoid taking sildenafil if you’re using nitrates.
Certain medications for high blood pressure, such as alpha-blockers, can also interact with sildenafil. Your doctor might adjust your dosage of either medication to manage potential side effects.
Some antifungal medications, like ketoconazole and itraconazole, can increase sildenafil levels in your blood, potentially leading to heightened side effects. Your physician may recommend a lower sildenafil dose.
Grapefruit juice can interfere with the metabolism of sildenafil, leading to increased blood levels. Avoid consuming grapefruit or grapefruit juice while taking sildenafil.
The following table summarizes some key interactions:
| Nitrates | Nitroglycerin, isosorbide dinitrate | Dangerous drop in blood pressure |
| Alpha-blockers | Terazosin, tamsulosin | Increased risk of low blood pressure |
| Azole antifungals | Ketoconazole, itraconazole | Increased sildenafil blood levels |
| Protease inhibitors | Ritonavir, indinavir | Increased sildenafil blood levels |
| Grapefruit juice | Grapefruit juice | Increased sildenafil blood levels |
This information is not exhaustive. Consult your doctor or pharmacist for a personalized assessment of potential interactions based on your specific medications and health conditions.
