Regular veterinary check-ups are crucial for cats on long-term prednisone. These visits allow for monitoring and adjustment of dosage as needed.
Increased Appetite and Weight Gain
Prednisone often stimulates appetite. This can lead to significant weight gain, increasing the risk of diabetes and other health problems. Monitor your cat’s food intake and weight closely. Your vet can advise on appropriate diet adjustments.
Increased Thirst and Urination (Polydipsia and Polyuria)
Increased water consumption and urination are common. This can strain the kidneys. Provide fresh water at all times and watch for any changes in urination patterns. Report any concerns promptly to your vet.
Weakened Immune System
Prednisone suppresses the immune system, making cats more susceptible to infections. Avoid exposing your cat to sick animals and maintain good hygiene.
Other Potential Side Effects
Other potential long-term side effects include: thinning of the skin, increased risk of skin infections, liver enzyme elevation, muscle weakness, and behavioral changes (e. g., increased aggression or lethargy).
Monitoring and Management
| Weight Gain | Regular weigh-ins | Dietary adjustments, increased exercise |
| Increased Thirst/Urination | Observe water intake and litter box usage | Vet consultation, potential medication adjustments |
| Skin Issues | Regular skin and coat checks | Topical treatments, veterinary care for infections |
| Behavioral Changes | Observe cat’s behavior and interactions | Vet consultation, potential behavioral modification |
Remember, the severity of side effects varies between cats. Open communication with your veterinarian is key for managing these potential risks and ensuring your cat’s well-being.
Regular Bloodwork
Your vet will likely recommend regular blood tests to monitor kidney and liver function, blood sugar levels, and overall health.


