Consider using hydrocortisone cream. This 1% topical steroid can significantly reduce itching and inflammation associated with a prednisone rash. Apply a thin layer to affected areas several times a day, following the product instructions. Avoid applying it to broken skin.
Antihistamines for Itching
Oral antihistamines, like diphenhydramine (Benadryl) or cetirizine (Zyrtec), can help manage the itch. Diphenhydramine can cause drowsiness, so take it before bedtime. Cetirizine is less likely to cause drowsiness but may still affect some individuals. Always follow label instructions.
Calamine lotion provides soothing relief from itching. It’s a gentle topical solution that can cool and calm irritated skin. Apply liberally to the rash as needed. Cool compresses can also offer additional comfort.
