Always inform your doctor about all medications you’re taking, including over-the-counter drugs, herbal supplements, and vitamins, before starting Lamictal. This includes prescription drugs for other conditions. Failure to do so could lead to unexpected side effects or reduced efficacy.
Certain medications increase the risk of serious interactions with Lamictal. These include:
- Valproic acid (Depakote): This increases Lamictal blood levels significantly, potentially causing serious side effects. Your doctor will carefully monitor your Lamictal dose if you’re also taking valproic acid. Oral contraceptives (birth control pills): Lamictal may decrease the effectiveness of birth control pills. Discuss alternative contraception methods with your doctor while on Lamictal. Certain antibiotics: Some antibiotics can impact Lamictal’s metabolism. Your doctor might adjust your Lamictal dose if you’re taking antibiotics. MAO inhibitors: Combining Lamictal with MAO inhibitors poses a risk of serotonin syndrome, a potentially life-threatening condition. These should not be used concurrently.
Other medications may have a milder interaction. Examples include:
- Aspirin and other NSAIDs: Increased bleeding risk is possible. Opioids: Increased drowsiness or sedation. Warfarin: May impact warfarin’s effectiveness and increase bleeding risk.
This list isn’t exhaustive. Your doctor or pharmacist can provide a more detailed explanation of potential interactions based on your individual medication profile. Always consult them before starting or stopping any medication while taking Lamictal. Regular blood tests may be needed to monitor your Lamictal levels and ensure safety.
Remember, proactive communication with your healthcare team is key to managing your medication safely and effectively.


