IUI without Clomid generally carries fewer side effects than IUI with Clomid. This is because Clomid is a medication that stimulates ovulation, and its side effects stem from this stimulation.
However, some potential risks remain, albeit generally mild:
- Ovarian Hyperstimulation Syndrome (OHSS): While less likely without Clomid, it’s still possible to experience mild OHSS. Symptoms include bloating, pelvic discomfort, and sometimes nausea. Severe OHSS is rare without ovarian stimulation medications. Multiple Pregnancy: The chance of twins or higher-order multiples is lower without Clomid than with Clomid, but it’s still a possibility with IUI. Your doctor will discuss this risk with you. Discomfort during the procedure: Some women experience mild cramping during the IUI procedure itself. This is usually temporary and easily managed. Emotional Stress: The fertility process can be emotionally taxing, regardless of the treatment method. Support systems and open communication with your doctor are invaluable.
It’s important to note:
The absence of Clomid significantly reduces the risk of the more serious side effects associated with ovarian hyperstimulation. Individual responses vary. Your personal risk profile depends on your individual health and medical history. Open communication with your fertility specialist is key to understanding and managing any potential risks or side effects.
Your doctor can provide personalized advice and monitor you closely throughout the process to minimize any potential complications. Remember to report any unusual symptoms promptly.


