Vitex agnus-castus exerts its effects primarily through its influence on the hypothalamic-pituitary-ovarian (HPO) axis. It achieves this by modulating dopamine levels. Specifically, Vitex appears to act as a dopamine D2 receptor antagonist, reducing dopamine’s inhibitory effect on prolactin release. Increased prolactin levels then stimulate the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Impact on Hormone Levels
This intricate hormonal interplay is crucial for regulating the menstrual cycle. Higher LH and FSH levels promote ovulation and support the development of the corpus luteum, which produces progesterone. A balanced hormonal environment is vital for fertility and regular menstruation. Studies suggest Vitex might improve follicle development and enhance the chances of conception in women with certain hormonal imbalances.
Considerations for Use with Femara
Femara (letrozole) is an aromatase inhibitor used to treat infertility. It works by lowering estrogen levels, indirectly increasing FSH and LH. The combined use of Vitex and Femara warrants careful consideration due to their shared impact on the HPO axis. Consult your physician to assess potential interactions and ensure safe and effective treatment.
