Begin with a low dose, typically 125-250 mg twice daily. Monitor intraocular pressure (IOP) closely. If IOP reduction is insufficient after two to four weeks, increase the dose in 250 mg increments at intervals of two to four weeks, up to a maximum of 1000 mg per day, divided into two or more doses.
Observe the patient for side effects. Common side effects like paresthesia, anorexia, or fatigue might necessitate dose reduction or alternative treatment. Closely track serum bicarbonate levels; a significant drop may signal the need for dose adjustment or discontinuation.
Individual responses vary significantly. Some patients achieve satisfactory IOP control with low doses, while others may require higher doses. Always prioritize patient safety and comfort. Regular IOP monitoring and close observation of side effects are paramount for optimizing treatment.
If the maximum dose provides inadequate IOP control, consider combining acetazolamide with other glaucoma medications or exploring alternative treatment options. Always consult with an ophthalmologist to develop a personalized treatment plan.
Remember that exceeding the maximum daily dose can increase the risk of serious side effects. Do not adjust the dosage without consulting a healthcare professional. Regular follow-up appointments are important to monitor treatment progress and make necessary adjustments.
