Choose Aleve (naproxen sodium) for quicker pain relief, especially for mild to moderate pain and inflammation. Meloxicam, however, offers longer-lasting relief, making it a better choice for chronic conditions requiring consistent pain management. This difference stems from their varying half-lives; naproxen’s is shorter, leading to faster onset but less duration, while meloxicam’s longer half-life provides sustained effects.
Both drugs belong to the NSAID (nonsteroidal anti-inflammatory drug) class, but they differ in their specific mechanisms. Naproxen inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin production responsible for pain and inflammation. Meloxicam primarily targets COX-2, reducing inflammation while potentially causing fewer gastrointestinal side effects than nonselective NSAIDs like ibuprofen. This doesn’t guarantee a lack of side effects, though.
| Onset of Action | Faster | Slower |
| Duration of Action | Shorter | Longer |
| COX Inhibition | Nonselective | Predominantly COX-2 selective |
| Typical Dosage | 220mg-440mg daily, divided doses | 7.5mg-15mg daily |
| Common Side Effects | Stomach upset, heartburn, increased risk of bleeding | Similar to naproxen, but potentially less GI upset |
Always consult your doctor before starting either medication. Dosage adjustments are crucial depending on individual health conditions and other medications taken. Both Aleve and meloxicam carry risks, including gastrointestinal bleeding and cardiovascular issues. Your doctor can help determine which medication is safer and more appropriate for your specific needs and health history. Self-treating can be harmful.
