Combining doxycycline hyclate and Benadryl can increase the risk of certain side effects. Drowsiness is a common one, potentially impacting your ability to drive or operate machinery. You might experience dizziness or lightheadedness, too. Pay close attention to your coordination and balance.
Gastrointestinal issues such as nausea, vomiting, or upset stomach are possible. Drinking plenty of water with both medications may help minimize these problems. If they’re severe, contact your doctor.
Both medications can cause dry mouth. Consider drinking more fluids or using sugar-free gum or lozenges to alleviate this. Dry eyes are another potential side effect.
Rarely, more serious reactions may occur. Seek immediate medical attention if you experience swelling of the face, lips, or tongue; difficulty breathing; or hives. These are signs of a potential allergic reaction.
Remember, this information isn’t a substitute for professional medical advice. Always consult your doctor or pharmacist before combining medications, particularly if you have pre-existing health conditions.


