Azithromycin, the active ingredient in Zithromax, can interact with several medications. Concurrent use with certain drugs may increase or decrease azithromycin’s effectiveness or cause adverse effects. Always inform your doctor or pharmacist of all medications you are taking, including over-the-counter drugs, herbal remedies, and supplements.
Ergot derivatives (e. g., ergotamine, dihydroergotamine): Combining azithromycin with these drugs may lead to ergotism, characterized by peripheral vasoconstriction. Avoid this combination.
Drugs metabolized by the liver (CYP3A4 substrates): Azithromycin inhibits CYP3A4, an enzyme responsible for metabolizing many medications. This interaction can elevate blood levels of drugs like statins (atorvastatin, simvastatin), leading to increased risk of myopathy or rhabdomyolysis. Close monitoring and potential dosage adjustments are necessary.
Digoxin: Azithromycin may increase digoxin levels, potentially causing toxicity. Regular monitoring of digoxin levels is advised.
Warfarin: Concomitant use may increase the risk of bleeding. Close monitoring of INR is recommended.
Anticoagulants: Beyond warfarin, other anticoagulants can have their effects altered by azithromycin. Physician supervision is crucial to manage this.
Note: This information is not exhaustive. Consult your physician or pharmacist for a complete list of potential drug interactions and personalized recommendations. Always carefully review your medication list with a healthcare provider before beginning treatment with Zithromax or any other medication.
