Famciclovir excels at shortening the duration and severity of cold sores compared to acyclovir, its related antiviral. While both reduce healing time, Famciclovir often requires less frequent dosing, making it more convenient for many. Acyclovir is available over-the-counter, offering easier access but potentially requiring more consistent application.
Topical Treatments
Topical creams like docosanol provide relief, but their impact on healing time is less dramatic than oral antivirals like Famciclovir. They primarily offer symptomatic relief, reducing pain and discomfort. While convenient and readily available, they are not as effective at preventing or shortening the outbreak itself. Consider topical treatments for minor outbreaks or in conjunction with oral medication for optimal results.
Pain Relief
Over-the-counter pain relievers, such as ibuprofen or acetaminophen, effectively manage cold sore pain and inflammation. While these medications won’t affect the virus directly, they significantly improve comfort during an outbreak. Remember to follow dosage instructions carefully.


