How Clomid Works in the Body

Clomid, or clomiphene citrate, acts by blocking estrogen receptors in your brain’s hypothalamus and pituitary gland. This blockage tricks your body into thinking estrogen levels are low.

In response, your pituitary gland releases more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones stimulate your ovaries to produce more follicles, the fluid-filled sacs that contain your eggs.

Increased FSH leads to multiple follicles developing simultaneously, increasing your chances of ovulation. The surge in LH triggers the release of a mature egg from one (or sometimes more) of these follicles, initiating ovulation.

Consequently, this hormonal cascade increases the likelihood of conception. However, the higher dose of FSH can sometimes lead to the development of multiple follicles, and, occasionally, ovarian cysts, if follicles do not fully mature and release eggs.