Long-Term Use, Treatment Alternatives, and When to See a Doctor

Avoid long-term clindamycin use for acne. Prolonged use increases the risk of Clostridium difficile infection and antibiotic resistance. Generally, doctors recommend a course of no more than three months.

Consider alternative treatments like benzoyl peroxide, topical retinoids (like tretinoin or adapalene), or azelaic acid. Oral medications, such as isotretinoin (for severe acne), may be necessary; however, these require close medical supervision due to potential side effects.

Schedule a doctor’s appointment if you experience persistent acne despite treatment, new or worsening symptoms (like severe inflammation or pus-filled lesions), diarrhea, or abdominal cramping. These could indicate an adverse reaction or a different underlying condition.

Your dermatologist can assess your skin, discuss your treatment history, and help you find the most appropriate acne management strategy. They can also determine whether alternative therapies or additional testing is required.

Always follow your doctor’s instructions precisely and discuss any concerns or questions you may have about your medication or treatment plan.