Patients with impaired renal function require valsartan dose adjustments. The recommended starting dose is typically lower, and maximum dose limitations apply.
Here’s a guideline based on creatinine clearance (CrCl):
- CrCl 30-79 mL/min: Start with a lower dose, usually 80 mg daily. Maximum daily dose: 160 mg, but individual titration is crucial based on patient response and tolerance. CrCl 10-29 mL/min: Start with an even lower dose, perhaps 40 mg daily. Maximum daily dose: 80 mg. Close monitoring is mandatory. CrCl Valsartan is generally not recommended. Alternatives should be considered given significant renal impairment.
Important Note: These are guidelines; individual patient needs vary. Always consult prescribing information and consider other factors like age, concurrent medications, and overall health status when determining the appropriate valsartan dose. Regular monitoring of renal function and blood pressure is vital.
Further Considerations:
Geriatric Patients: Older adults may require dose adjustments due to age-related decline in renal function. Start with a lower dose and monitor closely. Concurrent Medications: Interactions with other drugs may influence valsartan dosage. Check for potential interactions with the patient’s medication profile. Patient Response: Dosage adjustments should be based on individual patient response and tolerance, monitoring blood pressure regularly.
Always refer to the latest prescribing information for the most accurate and up-to-date guidance.
