Furosemide is a powerful loop diuretic, meaning it increases urine output by acting on the loop of Henle in your kidneys. This specific area is critical for sodium and water reabsorption.
Specifically, furosemide inhibits the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. Blocking this transporter prevents sodium, potassium, and chloride ions from being reabsorbed back into the bloodstream. This leads to increased excretion of these electrolytes along with water, resulting in diuresis (increased urine production).
The increased excretion of sodium consequently reduces blood volume and lowers blood pressure. This makes furosemide particularly useful in treating conditions like heart failure, edema (fluid retention), and hypertension (high blood pressure).
Remember: Furosemide’s effects on electrolyte balance are significant, and monitoring potassium levels is crucial during treatment to prevent hypokalemia (low potassium levels), a potential side effect. Your doctor will carefully manage your dosage and monitor your health while you are taking this medication.
In short: Furosemide blocks sodium reabsorption in the kidneys, leading to increased urine output and a reduction in blood pressure and fluid volume.
